Chapter 16 of the ENCePP Methodological Guide covers specific topics in comparative effectiveness research (CER), focusing on methods that use various data sources like randomized clinical trials (RCTs), observational data, and evidence synthesis. It also discusses approaches for relative effectiveness assessment (REA), emphasizing the importance of robust methodologies in real-world evidence (RWE) and hybrid studies combining RCT and RWD data. The chapter highlights practical guidelines for performing systematic reviews, meta-analyses, and ensuring compliance with regulatory standards.

For more details, visit ENCePP Chapter 16